A study of the digestibility of sorghum silage and oat straw

LD2668 .T4 1947 D68Master of Scienc

A Strong B-cell Response Is Part of the Immune Landscape in Human High-Grade Serous Ovarian Metastases

In high-grade serous ovarian cancer (HGSOC), higher densities of both B cells and the CD8 + T-cell infiltrate were associated with a better prognosis. However, the precise role of B cells in the antitumor response remains unknown. As peritoneal metastases are often responsible for relapse, our aim was to characterize the role of B cells in the antitumor immune response in HGSOC metastases. Unmatched pre and post-chemotherapy HGSOC metastases were studied. B-cell localization was assessed by immunostaining. Their cytokines and chemokines were measured by a multiplex assay, and their phenotype was assessed by flow cytometry. Further in vitro and in vivo assays highlighted the role of B cells and plasma cell IgGs in the development of cytotoxic responses and dendritic cell activation. B cells mainly infiltrated lymphoid structures in the stroma of HGSOC metastases. There was a strong B-cell memory response directed at a restricted repertoire of antigens and production of tumor-specific IgGs by plasma cells. These responses were enhanced by chemotherapy. Interestingly, transcript levels of CD20 correlated with markers of immune cytolytic responses and immune complexes with tumor-derived IgGs stimulated the expression of the costimulatory molecule CD86 on antigen-presenting cells. A positive role for B cells in the antitumor response was also supported by B-cell depletion in a syngeneic mouse model of peritoneal metastasis. Our data showed that B cells infiltrating HGSOC omental metastases support the development of an antitumor response. Clin Cancer Res; 1-13. ©2016 AACR

Neoadjuvant Chemotherapy Modulates the Immune Microenvironment in Metastases of Tubo-Ovarian High-Grade Serous Carcinoma

This research was funded by Swiss Cancer League (BIL KLS-2883-02-2012), the European Research Council (ERC322566), Cancer Research UK (A16354), and Barts and The London Charity (467/1307)

A Data-driven Model of Nucleosynthesis with Chemical Tagging in a Lower-dimensional Latent Space

Chemical tagging seeks to identify unique star formation sites from present-day stellar abundances. Previous techniques have treated each abundance dimension as being statistically independent, despite theoretical expectations that many elements can be produced by more than one nucleosynthetic process. In this work, we introduce a data-driven model of nucleosynthesis, where a set of latent factors (e.g., nucleosynthetic yields) contribute to all stars with different scores and clustering (e.g., chemical tagging) is modeled by a mixture of multivariate Gaussians in a lower-dimensional latent space. We use an exact method to simultaneously estimate the factor scores for each star, the partial assignment of each star to each cluster, and the latent factors common to all stars, even in the presence of missing data entries. We use an information-theoretic Bayesian principle to estimate the number of latent factors and clusters. Using the second Galah data release, we find that six latent factors are preferred to explain N = 2566 stars with 17 chemical abundances. We identify the rapid- and slow neutron-capture processes, as well as latent factors consistent with Fe-peak and α-element production, and another where K and Zn dominate. When we consider N ~ 160,000 stars with missing abundances, we find another seven factors, as well as 16 components in latent space. Despite these components showing separation in chemistry, which is explained through different yield contributions, none show significant structure in their positions or motions. We argue that more data and joint priors on cluster membership that are constrained by dynamical models are necessary to realize chemical tagging at a galactic-scale. We release accompanying software that scales well with the available data, allowing for the model's parameters to be optimized in seconds given a fixed number of latent factors, components, and ~107 abundance measurements.We acknowledge support from the Australian Research Council through Discovery Project DP160100637. J.B.H. is supported by a Laureate Fellowship from the Australian Research Council. Parts of this research were supported by the Australian Research Council (ARC) Centre of Excellence for All Sky Astrophysics in 3 Dimensions (ASTRO 3D), through project number CE170100013. S.~B. acknowledges funds from the Alexander von Humboldt Foundation in the framework of the Sofja Kovalevskaja Award endowed by the Federal Ministry of Education and Research. S.B. is supported by the Australian Research Council (grants DP150100250 and DP160103747). S.L.M. acknowledges the support of the UNSW Scientia Fellowship program. J.D.S., S.L.M., and D.B.Z. acknowledge the support of the Australian Research Council through Discovery Project grant DP180101791. The Galah survey is based on observations made at the Australian Astronomical Observatory, under programmes A/2013B/13, A/2014A/25, A/2015A/19, and A/2017A/18. We acknowledge the traditional owners of the land on which the AAT stands, the Gamilaraay people, and pay our respects to elders past and present. This research has made use of NASA’s Astrophysics Data System

Global diversification of a tropical plant growth form: environmental correlates and historical contingencies in climbing palms

Tropical rain forests (TRF) are the most diverse terrestrial biome on Earth, but the diversification dynamics of their constituent growth forms remain largely unexplored. Climbing plants contribute significantly to species diversity and ecosystem processes in TRF. We investigate the broad-scale patterns and drivers of species richness as well as the diversification history of climbing and non-climbing palms (Arecaceae). We quantify to what extent macroecological diversity patterns are related to contemporary climate, forest canopy height and paleoclimatic changes. We test whether diversification rates are higher for climbing than non-climbing palms and estimate the origin of the climbing habit. Climbers account for 22% of global palm species diversity mostly concentrated in Southeast Asia. Global variation in climbing palm species richness can be partly explained by past and present-day climate and rain forest canopy height, but regional differences in residual species richness after accounting for current and past differences in environment suggest a strong role of historical contingencies in climbing palm diversification. Climbing palms show a higher net diversification rate than non-climbers. Diversification analysis of palms detected a diversification rate increase along the branches leading to the most species-rich clade of climbers. Ancestral character reconstructions revealed that the climbing habit originated between early Eocene and Miocene. These results imply that changes from non-climbing to climbing habit may have played an important role in palm diversification, resulting in the origin of one fifth of all palm species. We suggest that, in addition to current climate and paleoclimatic changes after the late Neogene, present-day diversity of climbing palms can be explained by morpho-anatomical innovations, the biogeographic history of Southeast Asia, and/or ecological opportunities due to the diversification of high-stature dipterocarps in Asian TRFs

The housholders philosophie [electronic resource] : VVherein is perfectly and profitably described, the true oeconomia and forme of housekeeping. With a table added thereunto of all the notable thinges therein contained. First written in Italian by that excellent orator and poet Signior Torquato Tasso, and now translated by T.K. Whereunto is anexed a dairie booke for all good huswiues.

T.T. = Thomas Kyd.A translation of: Il padre di famiglia.Printer's name from STC."A dairie booke for good huswiues" by Bartholomew Dowe has separate dated title page and register.A reissue, with cancel general title page and Dowe's work added, of STC 23702.5.Includes index.Reproduction of the original in the Henry E. Huntington Library and Art Gallery.STC (2nd ed.)Electronic reproduction